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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN11 All Species: 17.58
Human Site: Y396 Identified Species: 38.67
UniProt: Q06124 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.3
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q06124 NP_002825.3 597 68436 Y396 K E S A A H D Y T L R E L K L
Chimpanzee Pan troglodytes XP_001164543 512 58884 K324 L R E L K L S K V G Q G N T E
Rhesus Macaque Macaca mulatta XP_001110915 597 67615 R395 D T T E Y K L R T L H V S P L
Dog Lupus familis XP_534686 571 65327 R384 L K E Y G V M R V R N V K E S
Cat Felis silvestris
Mouse Mus musculus P35235 597 68442 Y396 K E S A A H D Y T L R E L K L
Rat Rattus norvegicus P41499 597 68440 Y396 R E S A A H D Y T L R E L K L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519242 359 41028 L172 V M I R C Q D L K Y D V G G G
Chicken Gallus gallus Q90687 593 67964 Y396 K E S A A H D Y T L R E L K L
Frog Xenopus laevis NP_001084076 595 68232 Y396 K E T P A H D Y I L R E L K L
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29349 845 92957 N395 T S G V S S V N G P G T P T N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784121 533 60826 F346 R P M F H F H F K S W P D H G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.7 54 95.1 N.A. 99.5 98.9 N.A. 59.2 97.6 93.4 N.A. N.A. 38.5 N.A. N.A. 51.9
Protein Similarity: 100 85.7 70 95.1 N.A. 99.8 99.5 N.A. 60.1 98.4 95.8 N.A. N.A. 51.3 N.A. N.A. 65.8
P-Site Identity: 100 0 20 0 N.A. 100 93.3 N.A. 6.6 100 80 N.A. N.A. 0 N.A. N.A. 0
P-Site Similarity: 100 6.6 26.6 13.3 N.A. 100 100 N.A. 6.6 100 86.6 N.A. N.A. 6.6 N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 37 46 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 0 0 0 0 55 0 0 0 10 0 10 0 0 % D
% Glu: 0 46 19 10 0 0 0 0 0 0 0 46 0 10 10 % E
% Phe: 0 0 0 10 0 10 0 10 0 0 0 0 0 0 0 % F
% Gly: 0 0 10 0 10 0 0 0 10 10 10 10 10 10 19 % G
% His: 0 0 0 0 10 46 10 0 0 0 10 0 0 10 0 % H
% Ile: 0 0 10 0 0 0 0 0 10 0 0 0 0 0 0 % I
% Lys: 37 10 0 0 10 10 0 10 19 0 0 0 10 46 0 % K
% Leu: 19 0 0 10 0 10 10 10 0 55 0 0 46 0 55 % L
% Met: 0 10 10 0 0 0 10 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 10 0 0 10 0 10 0 10 % N
% Pro: 0 10 0 10 0 0 0 0 0 10 0 10 10 10 0 % P
% Gln: 0 0 0 0 0 10 0 0 0 0 10 0 0 0 0 % Q
% Arg: 19 10 0 10 0 0 0 19 0 10 46 0 0 0 0 % R
% Ser: 0 10 37 0 10 10 10 0 0 10 0 0 10 0 10 % S
% Thr: 10 10 19 0 0 0 0 0 46 0 0 10 0 19 0 % T
% Val: 10 0 0 10 0 10 10 0 19 0 0 28 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % W
% Tyr: 0 0 0 10 10 0 0 46 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _